Guggul or gum guggul is a resin obtained from the Commiphora mukul tree. Guggul has drawn a lot of attention from the scientific community due to its extraordinary benefits for the heart and blood cholesterol control. Guggul has been shown to lower cholesterol by upto 27% and also raise HDL. Natural plant sterols present in Guggul known as guggulsterones are key in Guggul's abilities to lower blood cholesterol, triglycerides and burn fat. When LDL cholesterol gets oxidized, it accumulates in arteries as plaque and causes atherosclerosis. Guggulsterones prevent oxidation of LDL cholesterol and block the formation of hydroxyl radicals that attack cell membranes. Guggulsterones also reduce production of cholesterol in the liver, stimulate production of thyroid hormones and increase the receptors in the liver for the uptake of LDL.