Bitter Melon
Benefits of Bitter Melon:
Controls blood sugar levels, detoxification, blood purifier
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Latin name: Momordica charantia
Common names: Bitter melon, bitter gourd, karela, sorci, balsam pear, balsam apple, melega saga.
Bitter melon is a vegetable that primarily grows in tropical regions. Every culture in which it is grown knows it for its medicinal properties. In many parts of India, it is made part of the regular diet especially during summer owing to bitter melon's cooling and digestive properties.
Bitter melon contains elements such as charantin, vicine and polypeptide-p. Bitter melon's metabolic and hypoglycemic effects have been shown in animal and human studies. As a consequence bitter melon is frequently recommended as a dietary supplement for diabetic and prediabetic patients.
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Himalaya Bitter Melon / Karela
60 Capsules per Bottle ; 250mg per capsule (Pure Herb Extract)
FREE Shipping on All Orders Worldwide!!!
Benefits of Bitter Melon
- Bitter Melon lowers blood sugar levels
- Bitter melon purifies blood
- Bitter melon has a salutary effect on liver and pancreas
- Bitter melon lowers sugar levels in urine
- Studies have shown bitter melon has an inbitory effect on colon cancer
- Bitter melon improves metabolism and food absorption
- Bitter melon is a detoxifying agent
- Bitter melon is useful in jaundice and piles
Directions for taking Bitter melon
1 capsule twice a day after meals.
Pure Bitter Melon Capsules from Himalaya Herbals
Himalaya Bitter melon is from the renowned Himalaya Herbals brand endorsed by over 250,000 doctors worldwide and used by customers in over 60 countries. Himalaya Herbals products have been researched clinically and standardized to guarantee bioequivalence. Bioequivalence refers to ensuring that the product on the market is equivalent to the one on which clinical trials were successfully conducted. Himalaya Herbal Healthcare uses chromatographic fingerprinting, one of the most sophisticated standardization techniques, to ensure consistent quality and performance
Bitter melon research and Clinical Studies
Antidiabetic activities of triterpenoids isolated from bitter melon associated with activation of the AMPK pathway.(1)
Four cucurbitane glycosides, momordicosides Q, R, S, and T, and stereochemistry-established karaviloside XI, were isolated from the vegetable bitter melon (Momordica charantia). These compounds and their aglycones exhibited a number of biologic effects beneficial to diabetes and obesity. In both L6 myotubes and 3T3-L1 adipocytes, they stimulated GLUT4 translocation to the cell membrane--an essential step for inducible glucose entry into cells. This was associated with increased activity of AMP-activated protein kinase (AMPK), a key pathway mediating glucose uptake and fatty acid oxidation. Furthermore, momordicoside(s) enhanced fatty acid oxidation and glucose disposal during glucose tolerance tests in both insulin-sensitive and insulin-resistant mice. These findings indicate that cucurbitane triterpenoids, the characteristic constituents of M. charantia, may provide leads as a class of therapeutics for diabetes and obesity.
Modulatory effect of bitter gourd (Momordica charantia LINN.) on alterations in kidney heparan sulfate in streptozotocin-induced diabetic rats.(2)
Glycoconjugates in the kidney play an important role in the maintenance of glomerular filtration barrier. Thickening of the glomerular basement membrane (GBM) is well characterized in diabetic nephropathy. Changes in GBM mainly include reduction and undersulfation of heparan sulfate, and laminin with accumulation of type IV collagen leading to kidney dysfunction and there is a need to identify therapies that arrest disease progression to end-stage renal failure. In the present investigation, effect of bitter gourd on streptozotocin-induced diabetic rats with particular emphasis on kidney heparan sulfate (HS) was studied. Earlier, our study showed partial reversal of all the diabetes-induced effects by bitter gourd. Increase in the components of glycoconjugates during diabetes was significantly decreased by bitter gourd feeding. Diabetes associated elevation in the activities of enzymes involved in the synthesis and degradation of glycosaminoglycans (GAGs) were significantly lowered by bitter gourd supplementation. GAGs composition revealed decrease in amino sugar, and uronic acid contents during diabetes and bitter gourd feeding was effective in countering this reduction. Decrease in sulfate content in the GAGs during diabetes was ameliorated by bitter gourd feeding. HS decreased by 43% in diabetic rats while bitter gourd feeding to diabetic rats showed 28% reduction. These results clearly indicate beneficial role of bitter gourd in controlling glycoconjugate and heparan sulfate related kidney complications during diabetes thus prolonging late complications of diabetes.
References:
(1)Chem Biol. 2008 Mar;15(3):263-73
Tan MJ, Ye JM, Turner N, Hohnen-Behrens C, Ke CQ, Tang CP, Chen T, Weiss HC, Gesing ER, Rowland A, James DE, Ye Y.
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, China.
(2)J Ethnopharmacol. 2008 Jan 17;115(2):276-83. Epub 2007 Oct 9. Links
Kumar GS, Shetty AK, Salimath PV.
Department of Biotechnology, Daegu University, Republic of Korea.
Articles on Diabetes and Karela:
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Easy ways to lead a healthy life and control diabetes
Blog entries on Bitter Melon
Bitter Melon health benefits
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